ChloroquineV1, Main, Exploration, bibRecord, 002842

Accelerated cutaneous nodulosis during methotrexate therapy in a patient with rheumatoid arthritis

Identifieur interne : 002842 ( Main/Exploration ); précédent : 002841; suivant : 002843

Accelerated cutaneous nodulosis during methotrexate therapy in a patient with rheumatoid arthritis

Auteurs : Francis M. Williams ; Philip R. Cohen ; Frank C. Arnett

Source :

Journal of the American Academy of Dermatology [ 0190-9622 ] ; 1998.

RBID : ISTEX:EC83343DF669FA24EFC7F4808817CDBE3D8189F7

English descriptors

Teeft :
- American academy, Aortic, Arnett, Arthritis, Arthritis rheum, Cardiac, Colchicine, Cutaneous, Dermatology, Dermis, Granuloma, Histiocyte, Lesion, Lymphocyte, Methotrexate, Methotrexate therapy, Neutrophil, Nodule, Nodulosis, Papule, Regurgitation, Rheum, Rheumatoid, Rheumatoid arthritis, Rheumatoid nodules, Rheumatoid nodulosis, Skin lesions, Subcutaneous, Synovitis, Valvular.

Abstract

Abstract: Rheumatoid nodulosis is characterized by multiple small subcutaneous granulomatous nodules typically located on the elbows in approximately 20% of patients with rheumatoid arthritis. Accelerated rheumatoid nodulosis, especially involving the hands and feet, has recently been reported in patients receiving methotrexate therapy for rheumatoid arthritis. We describe a woman with seropositive, erosive rheumatoid arthritis who, on two occasions, developed nonperiarticular subcutaneous nodules and new heart murmurs during methotrexate therapy, while her arthritis remained under good control. The nodules resolved after methotrexate was discontinued and recurred after methotrexate was reintroduced. They again resolved after methotrexate was stopped and colchicine was added. Her DNA oligotyping was positive for HLA-DRB1 * 0401 , a genetic risk factor associated with accelerated rheumatoid nodulosis. Cutaneous biopsy specimens revealed palisading granulomas and giant cells consistent with rheumatoid nodulosis. (J Am Acad Dermatol 1998;39:359-62.)

Url:

https://api.istex.fr/ark:/67375/6H6-C775F6D7-D/fulltext.pdf

DOI: 10.1016/S0190-9622(98)70390-1

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Rheumatoid nodulosis is characterized by multiple small subcutaneous granulomatous nodules typically located on the elbows in approximately 20% of patients with rheumatoid arthritis. Accelerated rheumatoid nodulosis, especially involving the hands and feet, has recently been reported in patients receiving methotrexate therapy for rheumatoid arthritis. We describe a woman with seropositive, erosive rheumatoid arthritis who, on two occasions, developed nonperiarticular subcutaneous nodules and new heart murmurs during methotrexate therapy, while her arthritis remained under good control. The nodules resolved after methotrexate was discontinued and recurred after methotrexate was reintroduced. They again resolved after methotrexate was stopped and colchicine was added. Her DNA oligotyping was positive for HLA-DRB1 * 0401 , a genetic risk factor associated with accelerated rheumatoid nodulosis. Cutaneous biopsy specimens revealed palisading granulomas and giant cells consistent with rheumatoid nodulosis. (J Am Acad Dermatol 1998;39:359-62.)</div>
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Accelerated cutaneous nodulosis during methotrexate therapy in a patient with rheumatoid arthritis

Accelerated cutaneous nodulosis during methotrexate therapy in a patient with rheumatoid arthritis

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri